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Excess nicotinamide is eliminated partly through a methylation pathway, meaning it consumes methyl donors in the process of excretion

To reduce irritation and lumps, it helps to rotate injection sites (dont inject the same spot repeatedly), inject into healthy skin (avoid bruised, scarred, inflamed, or irritated areas), and keep your routine consistent (many protocols are taken in the morning)

Human studies demonstrate sustained, dose-dependent increases in both GH and IGF-1 with subcutaneous administration [1]

Place the used syringe and needle into a biohazard sharps container, and then rub the injection site in a circular motion for 2-3 minutes, which will activate the vitamin and help ease any irritation at the injection site